NCT07282457

A Prospective, Randomized, Sham-controlled, Dose-finding Phase 1/2 Two-part Trial to Evaluate the Safety, Tolerability, and Efficacy of ZM-02 Injection in Patients With Advanced Retinitis Pigmentosa

Study Summary

This is a Phase 1/2, multi-center, randomized, sham-controlled, dose-escalation study evaluating ZM-02 in patients with advanced retinitis pigmentosa (RP).

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Interventions

ZM-02 (low dose)GENETIC

Single unilateral IVT injection of low-dose ZM-02 in the study eye

ZM-02 (high dose)GENETIC

Single unilateral IVT injection of high-dose ZM-02 in the study eye

ZM-02 (selected dose)GENETIC

Single unilateral IVT injection of selected-dose ZM-02 in the study eye

Sham injectionPROCEDURE

Sham IVT procedure in the study eye

Study Locations

No locations listed.

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026