Study Summary
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in CEA-positive advanced malignant tumors. The pharmacokinetic characteristics of CAR-T cell preparations for the treatment of patients with CEA-positive advanced malignancies were obtained and the recommended dose and infusion schedule.
Want to learn more about this trial?
Request More InfoInterventions
CEA-targeted CAR-T cellsBIOLOGICAL
Administration method: intravenous infusion； Subjects will receive conditioning therapy by Fludarabine and Cyclophosphamide before cell infusion.
CEA-targeted CAR-T cellsBIOLOGICAL
Administration method: intraperitoneal injection；Subjects will receive conditioning therapy by Fludarabine and Cyclophosphamide before cell infusion.
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| Shanxi Bethune Hospital | Taiyuan | Shanxi | China |
| Shanxi Bethune Hospital | Taiyuan | Shanxi | China |
| Shanxi Bethune Hospital | Taiyuan | Shanxi | China |