NCT07297667

A Phase I Study of GCAR1, a Chimeric Antigen Receptor (CAR) T-CELL Therapy for Participants With Selected Relapsed/Refractory GPNMB-Expressing Solid Tumours

Study Summary

Only enrolling in Canada. The purpose of this study is to identify the highest dose of GCAR1, a chimeric antigen receptor (CAR-T) cell therapy, that can be tolerated without causing very severe side effects, and to see what effects GCAR1 has on selected cancers

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Interventions

FludarabineDRUG
Assigned at enrollment
CyclophosphamideDRUG
Assigned at enrollment
GCAR1BIOLOGICAL
Dose escalation

Study Locations

FacilityCityStateCountry
Arthur J.E. Child Comprehensive Cancer CentreCalgaryAlbertaCanada
Ottawa Hospital Research InstituteOttawaOntarioCanada
University Health Network Princess Margaret HospitalTorontoOntarioCanada

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026