NCT03706326

Combination Therapy of Anti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for Advanced Esophageal Cancer

Study Summary

The study is to assess the safety and efficacy of the immunotherapies using anti-MUC1 CAR T cells and /or PD-1 knockout engineered T cells in the treatment of patients with advanced esophageal cancer.

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Interventions

Anti-MUC1 CAR-T cellsBIOLOGICAL
Using the T cells from the patients' blood to produce anti-MUC1 CAR-T Cells and then the cells will be infused back to the patients.
PD-1 knockout Engineered T cellsBIOLOGICAL
Using the T cells from the blood of the patients to prepare PD-1 knockout T cells, then the cells will be infused back to the patients.
CAR-T combined with PD-1 Knockout T cellsCOMBINATION_PRODUCT
Using the T cells from the blood of the patients to prepare anti-MUC1 CAR-T Cells and PD-1 knockout T cells, then the cells will be infused back to the patients

Study Locations

FacilityCityStateCountry
First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhouGuangdongChina
Professor Size ChenGuangzhouGuangdongChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026