NCT07807111

A Phase I/IIa Clinical Trial to Assess the Safety, Tolerability, and Efficacy of a Single Intravitreal Injection of SPVN20 Gene Therapy in Participants With Advanced Rod-Cone Dystrophy

Study Summary

This open-label, multi-center study is to evaluate the safety, tolerability, and efficacy of escalating doses of a gene therapy called SPVN20 administered via a single intravitreal injection in participants with advanced Rod-Cone Dystrophy.

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Interventions

SPVN20 (high dose)BIOLOGICAL
SPVN20
SPVN20 (medium dose)BIOLOGICAL
SPVN20
SPVN20 (low dose)BIOLOGICAL
SPVN20

Study Locations

FacilityCityStateCountry
Ghent University HospitalGhentBelgium
CHNO XV-XX Paris - CIC 1423ParisFrance
Royal Victoria Eye And Ear HospitalDublinIreland

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: October 12, 2026