NCT07010523

Exploratory Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Anti-Mesothelin CAR-T Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Study Summary

This is a single-arm, open-label, exploratory clinical study to evaluate the safety, tolerability and preliminary efficacy of Anti-Mesothelin CAR-T cell injection in patients with Mesothelin-positive advanced malignant solid tumors.

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Interventions

Anti-mesothelin CAR-T cellsBIOLOGICAL
D0: 0.1×10\^6/Kg\~1.0×10\^6/Kg; cells will be infused intravenously.
FludarabineDRUG
D-7 to D-3: Fludarabine (25 mg/m\^2/day) will be administered intravenously for 5 days.
CyclophosphamideDRUG
D-7 to D-3: Cyclophosphamide (300 mg/m\^2/day) will be administered intravenously for 5 days.

Study Locations

FacilityCityStateCountry
The First Affiliated Hospital Zhejiang University School of MedicineHangzhouChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026