Study Summary
This study is a single-center, open-label clinical trial of single-dose of CAR T-cells in subjects with relapsed/refractory hematologic malignancy.
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Request More InfoInterventions
anti-CD19-CAR T-cells, or anti-CD30-CAR T-cells, or anti-CD20/CD30-CAR T-cellsBIOLOGICAL
Each subject will be infused with single dose. A classic "3+3" dose escalation will be employed.
anti-CD19-CAR T-cells
Dose level 1:1x10\^5 CAR T cells/kg, Dose level 2:3x10\^5 CAR T cells/kg, Dose level 3:1x10\^6 CAR T cells/kg
anti-CD30-CAR T-cells
Dose level 1:3x10\^6 CAR T cells/kg, Dose level 2:6x10\^6 CAR T cells/kg, Dose level 3:1x10\^7 CAR T cells/kg
anti-CD20/CD30-CAR T-cells
Dose level 1:1x10\^6 CAR T cells/kg, Dose level 2:3x10\^6 CAR T cells/kg, Dose level 3:1x10\^7 CAR T cells/kg
FludarabineDRUG
Fludarabine will be given at a dose of 25 mg/m\^2/day intravenously (IV) for 3 days prior to the infusion of CAR T-cells.
CyclophosphamideDRUG
Cyclophosphamide will be given at a dose of 250 mg/m\^2/day intravenously (IV) for 3 days prior to the infusion of CAR T-cells.
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| Affiliated Hospital of Nantong University | Nantong | Jiangsu | China |