NCT06756321

An Exploratory Clinical Study of the Safety and Efficacy of Chimeric Antigen Receptor T-Cells (CAR T-Cells) in Subjects with Relapsed/Refractory Hematologic Malignancy

Study Summary

This study is a single-center, open-label clinical trial of single-dose of CAR T-cells in subjects with relapsed/refractory hematologic malignancy.

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Interventions

anti-CD19-CAR T-cells, or anti-CD30-CAR T-cells, or anti-CD20/CD30-CAR T-cellsBIOLOGICAL
Each subject will be infused with single dose. A classic "3+3" dose escalation will be employed. anti-CD19-CAR T-cells Dose level 1:1x10\^5 CAR T cells/kg, Dose level 2:3x10\^5 CAR T cells/kg, Dose level 3:1x10\^6 CAR T cells/kg anti-CD30-CAR T-cells Dose level 1:3x10\^6 CAR T cells/kg, Dose level 2:6x10\^6 CAR T cells/kg, Dose level 3:1x10\^7 CAR T cells/kg anti-CD20/CD30-CAR T-cells Dose level 1:1x10\^6 CAR T cells/kg, Dose level 2:3x10\^6 CAR T cells/kg, Dose level 3:1x10\^7 CAR T cells/kg
FludarabineDRUG
Fludarabine will be given at a dose of 25 mg/m\^2/day intravenously (IV) for 3 days prior to the infusion of CAR T-cells.
CyclophosphamideDRUG
Cyclophosphamide will be given at a dose of 250 mg/m\^2/day intravenously (IV) for 3 days prior to the infusion of CAR T-cells.

Study Locations

FacilityCityStateCountry
Affiliated Hospital of Nantong UniversityNantongJiangsuChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026