NCT05667506

A Phase Ib/II, Single Arm, Multi-center Study Evaluating the Safety and Efficacy of CNCT19 in Children and Adolescent(Pediatric) Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r B-ALL)

Study Summary

This is a multi-center, phase Ib/II trial to evaluate the safety and efficacy of CNCT19 treatment in Children and Adolescent (pediatric) patients with relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-cell ALL).

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Interventions

single dose of CNCT19BIOLOGICAL
Autologous 2nd generation CD19-directed CAR-T cells, single infusion intravenously. Lymphodepletion treatment: Drugs:Fludarabine Drugs: Cyclophosphamide

Study Locations

FacilityCityStateCountry
The Second Hospital of Anhui Medical UniversityHefeiAnhuiChina
Children's Hospital of Chongqing Medical UniversityChongqingChongqing MunicipalityChina
Guangzhou Women and Children's Medical CenterGuangzhouGuangdongChina
Nanfang HospitalGuangzhouGuangdongChina
Union Hospital Tongji Medical College Huazhong University of Science of TechnologyWuhanHubeiChina
Children's Hospital of Nanjing Medical UniversityNanjingJiangsuChina
The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina
The First Affilicated Hospital of Nanchang UniversityNanchangJiangxiChina
Institute of Hematology & Blood Diseases HospitalTianjinTianjin MunicipalityChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026