NCT05651178

A Early Phase 1 Clinical Trial to Evaluate the Safety and Efficacy of Human CD19-CD22 Targeted T Cells Injection for Subjects with Central Nervous System Involvement of Refractory/Relapsed B Cell Malignancies

Study Summary

This study is a open-label, dose-escalation trial to explore the safety, tolerability and pharmacokinetic/pharmacodynamics characteristics of Human CD19-CD22 Targeted T Cells by intravenous and intrathecal administration, and to preliminarily observe the efficacy of the trial drug in patients with central nervous system involvement of refractory/relapsed B cell malignancies.

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Interventions

Human CD19-CD22 Targeted T Cells InjectionDRUG
Autologous genetically modified anti-CD19/CD22 CAR transduced T cells

Study Locations

FacilityCityStateCountry
The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxiChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026