NCT05531708

Safety and Efficacy Study of Novel Mesothelin CAR-T Cell Therapy in Patients With Mesothelin-positive Advanced Refractory Solid Tumors

Study Summary

This is a single-arm, open-label, exploratory clinical study to evaluate the safety and efficacy of novel Mesothelin CAR-T in patients with Mesothelin-positive advanced refractory solid tumors.

Want to learn more about this trial?

Request More Info

Interventions

Anti-mesothelin CAR-T cellsBIOLOGICAL
D0: Anti-mesothelin CAR-T cells are autologous genetically modified T cells. Cells will be infused intravenously.
FludarabineDRUG
D-7 to D-3: Fludarabine (25 mg/m\^2/day) will be administered intravenously for 5 days.
CyclophosphamideDRUG
D-7 and D-6: Cyclophosphamide (60 mg/kg/day) will be administered intravenously for 2 days.

Study Locations

FacilityCityStateCountry
Shanghai Pudong Hospital, Fudan University Affiliated Pudong Medical CenterShanghaiShanghai MunicipalityChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026