NCT05420545

A Phase I Clinical Study of CD70-targeting CAR-T Therapy in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors

Study Summary

This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CD70-positive advanced/metastatic solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.

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Interventions

CD70 CAR-T cellsBIOLOGICAL
Administration method: intravenous infusion; Subjects will be treated with Fludarabine and Cyclophosphamide before cell infusion.
CD70 CAR-T cellsBIOLOGICAL
Administration method: intraperitoneal injection; Subjects will be treated with Fludarabine and Cyclophosphamide before cell infusion.

Study Locations

FacilityCityStateCountry
The Second People's Hospital of Shandong ProvinceJinanShandongChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026