Study Summary
In this phase I study, the investigators will first evaluate the safety of CAR20.19.22 T-cells in patients with B-cell non-Hodgkin lymphoma (NHL) / chronic lymphocytic leukemia (CLL).
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Request More InfoInterventions
0.75x10^6 cells/kg CAR20.19.22 cellsBIOLOGICAL
Dose escalation: CAR20.19.22 cells will be administered at one of three dose levels either fresh or thawed after cryopreservation by IV injection.
Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.
1x10^6 cells/kg CAR20.19.22 cellsBIOLOGICAL
CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.
Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.
2.5x10^6 cells/kg CAR20.19.22 cellsBIOLOGICAL
CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.
The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.
5x10^6 cells/kg CAR20.19.22 cellsBIOLOGICAL
CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.
The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.
Dose expansion: The maximum tolerated dose of CAR20.19.22 cellsBIOLOGICAL
Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6 cells/kg.
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| Medical College of Wisconsin and Froedtert Hospital | Milwaukee | Wisconsin | United States |