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NCT04981119

An Observational Study Obtaining Solid Tumor Tissue From Participants and Apheresis for CAR T-Cell Therapy Manufacturing

Study Summary

Objective: To collect information on how often a solid tumor cancer might lose the Human Leukocyte Antigen (HLA) by next generation sequencing and perform apheresis to collect and store an eligible participant's own T cells for future use to make CAR T-Cell therapy for their disease treatment. Design: This is a non-interventional, observational study to evaluate participants with solid tumors with a high risk of relapse for incurable disease. No interventional therapy will be administered on this study. Some of the information regarding the participant's tumor analysis may be beneficial to management of their disease. Participants that meet all criteria may be enrolled and leukapheresed (blood cells collected). The participant's cells will be processed and stored for potential manufacture of CAR T-cell therapy upon relapse of their cancer.

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Interventions

ApheresisOTHER
Apheresis procedure performed for collection of PBMCs.
Next Generation Sequencing (NGS)DIAGNOSTIC_TEST
NGS on tumor tissue and a matched normal sample for loss of heterozygosity in tumor tissue and tumor tissue markers.
Long Range NGS HLA typingDIAGNOSTIC_TEST
Long range NGS on whole blood to determine germline HLA type.

Study Locations

FacilityCityStateCountry
Banner HealthGilbertArizonaUnited States
Mayo Clinic HospitalPhoenixArizonaUnited States
City of HopeDuarteCaliforniaUnited States
University of California San DiegoLa JollaCaliforniaUnited States
Stanford UniversityPalo AltoCaliforniaUnited States
UCLA Medical CenterSanta MonicaCaliforniaUnited States
Mayo Clinic JacksonvilleJacksonvilleFloridaUnited States
Moffitt Cancer CenterTampaFloridaUnited States
Massachusetts General Hospital/Dana Farber Cancer InstituteBostonMassachusettsUnited States
Mayo Clinic RochesterRochesterMinnesotaUnited States
Washington UniversitySt LouisMissouriUnited States
NYU Langone Medical CenterNew YorkNew YorkUnited States
The Ohio State University Comprehensive Cancer CenterColumbusOhioUnited States
Vanderbilt University Medical CenterNashvilleTennesseeUnited States
MD Anderson Cancer CenterHoustonTexasUnited States
Fred Hutchinson Cancer CenterSeattleWashingtonUnited States

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026