Study Summary
This is an open-label Phase 1 study to determine the feasibility, safety, and the recommended maximum tolerated Dose (MTD) of a single infusion of RPM CD19 mbIL15 CAR-T cells for adult patients. Approximately 24 subjects will be enrolled and it is anticipated approximately 16 subjects will be infused at the varied doses of T cells.
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RPM CD19-mbIL15-CAR-T cellsBIOLOGICAL
Single dose of RPM CD19-mbIL15-CAR-T cells will be infused, and a standard "3+3" design will be applied.
Drug: Fludarabine
Fludarabine is used for lymphodepletion.
Drug: Cyclophosphamide
Cyclophosphamide is used for lymphodepletion
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| National Taiwan University Hospital | Taipei | Taiwan |