NCT04789408

A Phase 1 Open-label, Multicenter Study Evaluating the Safety of KITE-222, an Autologous Anti-CLL-1 CAR T-cell Therapy, in Subjects With Relapsed/Refractory Acute Myeloid Leukemia

Study Summary

The goal of this clinical study is to learn more about the safety and dosing of the study drug, KITE-222, in participants with relapsed/refractory (r/r) acute myeloid leukemia (AML).

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Interventions

CyclophosphamideDRUG
Administered intravenously
FludarabineDRUG
Administered intravenously
KITE-222BIOLOGICAL
A single infusion of chimeric antigen receptor (CAR)-transduced autologous T cells administered intravenously

Study Locations

FacilityCityStateCountry
Stanford Cancer CenterStanfordCaliforniaUnited States
Moffitt Cancer CenterTampaFloridaUnited States
Washington University School of MedicineSt LouisMissouriUnited States
Cleveland ClinicClevelandOhioUnited States
The Ohio State University Wexner Medical Center/James Cancer HospitalColumbusOhioUnited States
The University of Texas MD Anderson Cancer CenterHoustonTexasUnited States
Fred Hutchinson Cancer CenterSeattleWashingtonUnited States
Institut Paoli-CalmettesMarseilleFrance
CHU de Toulouse Institut Universitaire du Cancer Toulouse OncopoleToulouseFrance

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026