Study Summary
This phase III trial compares the effect of usual treatment of chemotherapy and steroids and a tyrosine kinase inhibitor (TKI) to the same treatment plus blinatumomab. Blinatumomab is a Bi-specific T-Cell Engager ('BiTE') that may interfere with the ability of cancer cells to grow and spread. The information gained from this study may help researchers determine if combination therapy with steroids, TKIs, and blinatumomab work better than the standard of care.
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Request More InfoInterventions
Biospecimen CollectionPROCEDURE
Correlative studies
BlinatumomabBIOLOGICAL
Given IV
Bone Marrow Aspiration and BiopsyPROCEDURE
Undergo bone marrow aspiration and biopsy
CyclophosphamideDRUG
Given IV
CytarabineDRUG
Given IV or IT
DasatinibDRUG
Given PO
DexamethasoneDRUG
Given PO or IV
Doxorubicin HydrochlorideDRUG
Given IV
Echocardiography TestPROCEDURE
Undergo ECHO
ElectrocardiographyPROCEDURE
Undergo ECG
Lumbar PuncturePROCEDURE
Undergo lumbar puncture
MesnaDRUG
Given IV
MethotrexateDRUG
Given IV or IT
Multigated Acquisition ScanPROCEDURE
Undergo MUGA
Ponatinib HydrochlorideDRUG
Given PO
PrednisoneDRUG
Given PO
Vincristine SulfateDRUG
Given IV
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States |
| Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States |
| Anchorage Radiation Therapy Center | Anchorage | Alaska | United States |
| Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States |
| Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States |
| Alaska Women's Cancer Care | Anchorage | Alaska | United States |
| Anchorage Oncology Centre | Anchorage | Alaska | United States |
| Katmai Oncology Group | Anchorage | Alaska | United States |
| Providence Alaska Medical Center | Anchorage | Alaska | United States |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States |
| Community Cancer Institute | Clovis | California | United States |
| University Oncology Associates | Clovis | California | United States |
| City of Hope Comprehensive Cancer Center | Duarte | California | United States |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | United States |
| UC San Diego Moores Cancer Center | La Jolla | California | United States |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States |
| Yale University | New Haven | Connecticut | United States |
| Augusta University Medical Center | Augusta | Georgia | United States |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States |
| Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States |
| Queen's Medical Center | Honolulu | Hawaii | United States |
| Straub Clinic and Hospital | Honolulu | Hawaii | United States |
| University of Hawaii Cancer Center | Honolulu | Hawaii | United States |
| Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States |
| Kuakini Medical Center | Honolulu | Hawaii | United States |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States |
| The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States |
| Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States |
| Hawaii Cancer Care - Westridge | ‘Aiea | Hawaii | United States |
| Pali Momi Medical Center | ‘Aiea | Hawaii | United States |
| Queen's Cancer Center - Pearlridge | ‘Aiea | Hawaii | United States |
| The Cancer Center of Hawaii-Pali Momi | ‘Aiea | Hawaii | United States |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | United States |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States |
| OSF Saint Anthony's Health Center | Alton | Illinois | United States |
| Loyola Center for Health at Burr Ridge | Burr Ridge | Illinois | United States |
| Northwestern University | Chicago | Illinois | United States |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States |
| Loyola Medicine Homer Glen | Homer Glen | Illinois | United States |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States |
| Loyola University Medical Center | Maywood | Illinois | United States |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois | United States |
| SSM Health Good Samaritan | Mount Vernon | Illinois | United States |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States |
| Mary Greeley Medical Center | Ames | Iowa | United States |
| McFarland Clinic - Ames | Ames | Iowa | United States |
| McFarland Clinic - Boone | Boone | Iowa | United States |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | United States |
| McFarland Clinic - Jefferson | Jefferson | Iowa | United States |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | United States |
| Central Care Cancer Center - Garden City | Garden City | Kansas | United States |
| Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States |
| University of Kansas Cancer Center | Kansas City | Kansas | United States |
| University of Kansas Hospital-Indian Creek Campus | Overland Park | Kansas | United States |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States |
| UofL Health Medical Center Northeast | Louisville | Kentucky | United States |
| LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States |
| Walter Reed National Military Medical Center | Bethesda | Maryland | United States |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | United States |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | United States |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | United States |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | United States |
| Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | United States |
| Trinity Health Medical Center - Canton | Canton | Michigan | United States |
| Chelsea Hospital | Chelsea | Michigan | United States |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | United States |
| Hematology Oncology Consultants-Clarkston | Clarkston | Michigan | United States |
| Newland Medical Associates-Clarkston | Clarkston | Michigan | United States |
| Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States |
| Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States |
| Henry Ford Hospital | Detroit | Michigan | United States |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States |
| Cancer Hematology Centers - Flint | Flint | Michigan | United States |
| Genesee Hematology Oncology PC | Flint | Michigan | United States |
| Genesys Hurley Cancer Institute | Flint | Michigan | United States |
| Hurley Medical Center | Flint | Michigan | United States |
| Allegiance Health | Jackson | Michigan | United States |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States |
| Henry Ford Saint John Hospital - Macomb Medical | Macomb | Michigan | United States |
| Henry Ford Medical Center-Columbus | Novi | Michigan | United States |
| Michigan Healthcare Professionals Pontiac | Pontiac | Michigan | United States |
| Newland Medical Associates-Pontiac | Pontiac | Michigan | United States |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | United States |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | United States |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | United States |
| Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan | United States |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | United States |
| Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | United States |
| Henry Ford Wyandotte Hospital | Wyandotte | Michigan | United States |
| Huron Gastroenterology PC | Ypsilanti | Michigan | United States |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | United States |
| Mayo Clinic in Rochester | Rochester | Minnesota | United States |
| Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States |
| Mercy Oncology and Hematology - Clayton-Clarkson | Ballwin | Missouri | United States |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | United States |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States |
| Freeman Health System | Joplin | Missouri | United States |
| Mercy Hospital Joplin | Joplin | Missouri | United States |
| Research Medical Center | Kansas City | Missouri | United States |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States |
| Phelps Health Delbert Day Cancer Institute | Rolla | Missouri | United States |
| Heartland Regional Medical Center | Saint Joseph | Missouri | United States |
| Mercy Hospital Springfield | Springfield | Missouri | United States |
| CoxHealth South Hospital | Springfield | Missouri | United States |
| Mercy Infusion Center - Chippewa | St Louis | Missouri | United States |
| Washington University School of Medicine | St Louis | Missouri | United States |
| Mercy Hospital South | St Louis | Missouri | United States |
| Siteman Cancer Center-South County | St Louis | Missouri | United States |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | United States |
| Mercy Hospital Saint Louis | St Louis | Missouri | United States |
| Mercy Hospital Washington | Washington | Missouri | United States |
| Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States |
| Monmouth Medical Center | Long Branch | New Jersey | United States |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | United States |
| University of Rochester | Rochester | New York | United States |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | United States |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | United States |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States |
| Duke University Medical Center | Durham | North Carolina | United States |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States |
| Case Western Reserve University | Cleveland | Ohio | United States |
| MetroHealth Medical Center | Cleveland | Ohio | United States |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States |
| Saint Charles Health System | Bend | Oregon | United States |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | United States |
| Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States |
| Bay Area Hospital | Coos Bay | Oregon | United States |
| Providence Newberg Medical Center | Newberg | Oregon | United States |
| Providence Willamette Falls Medical Center | Oregon City | Oregon | United States |
| Providence Portland Medical Center | Portland | Oregon | United States |
| Providence Saint Vincent Medical Center | Portland | Oregon | United States |
| Saint Charles Health System-Redmond | Redmond | Oregon | United States |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States |
| Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States |
| Geisinger Medical Center | Danville | Pennsylvania | United States |
| Pocono Medical Center | East Stroudsburg | Pennsylvania | United States |
| Lehigh Valley Hospital-Hazleton | Hazleton | Pennsylvania | United States |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States |
| Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina | United States |
| Medical University of South Carolina | Charleston | South Carolina | United States |
| Prisma Health Cancer Institute - Easley | Easley | South Carolina | United States |
| Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | United States |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States |
| Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | United States |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States |
| Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | United States |
| Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States |
| Houston Methodist Hospital | Houston | Texas | United States |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States |
| University of Vermont Medical Center | Burlington | Vermont | United States |
| University of Vermont and State Agricultural College | Burlington | Vermont | United States |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | United States |
| Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States |
| PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States |
| Providence Regional Cancer System-Centralia | Centralia | Washington | United States |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States |
| Providence Regional Cancer Partnership | Everett | Washington | United States |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States |
| Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States |
| Providence Regional Cancer System-Lacey | Lacey | Washington | United States |
| PeaceHealth Saint John Medical Center | Longview | Washington | United States |
| Pacific Gynecology Specialists | Seattle | Washington | United States |
| Swedish Medical Center-Ballard Campus | Seattle | Washington | United States |
| Swedish Medical Center-Cherry Hill | Seattle | Washington | United States |
| Swedish Medical Center-First Hill | Seattle | Washington | United States |
| PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States |
| Providence Regional Cancer System-Shelton | Shelton | Washington | United States |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | United States |
| Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States |
| Providence Regional Cancer System-Yelm | Yelm | Washington | United States |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | United States |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | United States |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States |
| Medical College of Wisconsin | Milwaukee | Wisconsin | United States |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | United States |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States |
| Marshfield Medical Center - Weston | Weston | Wisconsin | United States |
| Rambam Medical Center | Haifa | Israel | |
| Shaare Zedek Medical Center | Jerusalem | Israel | |
| Centro Comprensivo de Cancer de UPR | San Juan | Puerto Rico | |
| San Juan City Hospital | San Juan | Puerto Rico |