NCT04272554

Screening/Observational Protocol to Determine Patient Eligibility for Inclusion in AAV Gene Therapy Clinical Trials (ECLIPSE)

Study Summary

Freeline is developing adeno-associated virus (AAV) vector based gene therapies for a number of diseases and is actively advancing a programme in Haemophilia B (HB). This study aims to collect prospective data to characterise bleeding events and Factor IX (FIX) concentrate consumption in HB patients that can be used as baseline for participants who elect to participate in a subsequent Freeline gene therapy study. The study will also screen participants for antibodies to a novel AAV vector to assess their suitability for inclusion in a Freeline gene therapy treatment study.

Want to learn more about this trial?

Request More Info

Interventions

No interventions listed.

Study Locations

FacilityCityStateCountry
Phoenix Childrens HospitalPhoenixArizonaUnited States
Children's Hospital of Los AngelesLos AngelesCaliforniaUnited States
University of California - DavisSacramentoCaliforniaUnited States
University of South FloridaTampaFloridaUnited States
Rush University Medical CenterChicagoIllinoisUnited States
Indiana Hemophilia and Thrombosis CenterIndianapolisIndianaUnited States
University of MichiganAnn ArborMichiganUnited States
University of Nebraska Medical CenterOmahaNebraskaUnited States
Hemophilia Center of Western New YorkBuffaloNew YorkUnited States
University of North Carolina (UNC)Chapel HillNorth CarolinaUnited States
East Carolina UniversityGreenvilleNorth CarolinaUnited States
University Hospitals Cleveland Medical CenterClevelandOhioUnited States
Nationwide Childrens HospitalColumbusOhioUnited States
St. Jude Children's Research HospitalMemphisTennesseeUnited States
Vanderbilt University Medical CenterNashvilleTennesseeUnited States
Lombardi Comprehensive Cancer Center at Georgetown UniversityGeorgetownWashingtonUnited States
Blood Center of WisconsinMilwaukeeWisconsinUnited States
Royal Children's Hospital, ParkvilleMelbourneAustralia
The Alfred HospitalMelbourneAustralia
Calvary Mater HospitalNewcastleAustralia
Royal Prince Alfred HospitalSydneyAustralia
Westmead HospitalSydneyAustralia
Medical University of ViennaViennaAustria
McMaster University Medical CentreHamiltonCanada
Lawson Health Research InstituteLondonCanada
The Moncton HospitalMonctonCanada
Saskatoon City HospitalSaskatoonCanada
University of Alberta HospitalWinnipegCanada
Hôpital Louis Pradel - HCLBronFrance
CHU BicetreParisFrance
Hopital Necker-Enfants Malades - AP-HPParisFrance
Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe UniversitaetFrankfurtGermany
Universitaetsklinikum des Saarlandes und Medizinische Fakultaet der Universitaet des SaarlandesHomburgGermany
St James HospitalDublinIreland
Azienda Ospedaliero-Universitaria CareggiFlorenceItaly
Istituto Giannina GasliniGenovaItaly
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di MilanoMilanItaly
Citta della Salute e della Scienza di Torino - Ospedale le MolinetteTorinoItaly
Groningen UMCGroningenNetherlands
Erasmus MCRotterdamNetherlands
Universitair Medisch Centrum UtrechtUtrechtNetherlands
University of Cape Town Clinical Research CenterCape TownSouth Africa
Charlotte Maxeke Johannesburg Academic HospitalJohannesburgSouth Africa
Istanbul University Faculty of MedicineIstanbulTurkey (Türkiye)
Ege University Medical FacultyIzmirTurkey (Türkiye)
Samsun Ondokuz Mayis University Medical FacultySamsunTurkey (Türkiye)
Özel Acibadem Adana HastanesiSeyhanTurkey (Türkiye)
The Haemophilia and Thrombosis CentreCanterburyKentUnited Kingdom
Queen Elizabeth HospitalBirminghamUnited Kingdom
Cardiff University HospitalCardiffUnited Kingdom
Glasgow Royal InfirmaryGlasgowUnited Kingdom
Hammersmith HospitalLondonUnited Kingdom
Royal Free London NHS Foundation TustLondonUnited Kingdom
St Thomas' HospitalLondonUnited Kingdom
Manchester Royal InfirmaryManchesterUnited Kingdom
Newcastle Hemophilia Comprehensive Care CentreNewcastleUnited Kingdom

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026