NCT03919526

The Safety and Clinical Efficacy of Human CD19/CD22 Bispecific Chimeric Antigen Receptor (CAR)-T Cell Therapy for Subjects With Measurable Residual Disease(MRD)-Positive B Cell Acute Lymphoblastic Leukemia

Study Summary

To evaluate the safety and efficacy of CD19/CD22 Bispecific chimeric antigen receptor (CAR)-T for the treatment of measurable residual disaese (MRD)-positive B cell acute lymphoblastic leukemia. Patients will be given a conditioning chemotherapy regimen of fludarabine and cyclophosphamide followed by a single infusion of CD19/CD22 CAR+ T cells.

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Interventions

anti-CD19/CD22 CAR-T cellsBIOLOGICAL
Retroviral vector-transduced autologous T cells to express anti-CD19 and anti-CD22 CARs
FludarabineDRUG
30mg/m2/d
CyclophosphamideDRUG
300mg/m2/d

Study Locations

FacilityCityStateCountry
Shanghai General HospitalShanghaiShanghai MunicipalityChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026