Study Summary
This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL, r/r B-cell NHL and CLL/SLL.
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Azer-celBIOLOGICAL
Infusion of Allogeneic Anti-CD19 CAR T cells
FludarabineDRUG
Specified dose on specified days
CyclophosphamideDRUG
Specified dose on specified days
IL-2DRUG
Specified dose on specified days
Study Locations
| Facility | City | State | Country |
|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | United States |
| City of Hope | Duarte | California | United States |
| H. Lee Moffitt Cancer Center | Tampa | Florida | United States |
| Winship Cancer Institute Emory University | Atlanta | Georgia | United States |
| Northside Hospital Cancer Institute | Atlanta | Georgia | United States |
| University of Maryland | Baltimore | Maryland | United States |
| Tufts Medical Center | Boston | Massachusetts | United States |
| Dana-Farber Cancer Institute | Boston | Massachusetts | United States |
| Barbara Ann Karmanos Cancer Institute (Wayne State University) | Detroit | Michigan | United States |
| University of Minnesota | Minneapolis | Minnesota | United States |
| Weill Cornell Medical College - NY Presbyterian Hospital | New York | New York | United States |
| Columbia University Irving Medical Center/New York Presbyterian Hospital | New York | New York | United States |
| Duke University | Durham | North Carolina | United States |
| Ohio State University | Columbus | Ohio | United States |
| Lifespan Cancer Institute at Rhode Island Hospital | Providence | Rhode Island | United States |
| Baylor University Medical Center | Dallas | Texas | United States |
| MD Anderson | Houston | Texas | United States |
| Medical College of Wisconsin | Milwaukee | Wisconsin | United States |
| Royal Prince Alfred Hospital | Camperdown | New South Wales | Australia |
| Liverpool Hospital | Liverpool | New South Wales | Australia |
| Royal Adelaide Hospital | Adelaide | South Australia | Australia |
| St Vincent's Hospital Melbourne | Fitzroy | Victoria | Australia |
| Barwon Health - Andrew Love Cancer Centre | Geelong | Victoria | Australia |