NCT03277729

A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

Study Summary

The purpose of this research is to find the best dose of genetically modified T-cells, to study the safety of this treatment, and to see how well it works in treating patients with B cell non-Hodgkin lymphoma that has come back (relapsed) or did not respond to previous treatment (refractory).

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Interventions

Chimeric Antigen Receptor T-Cell TherapyBIOLOGICAL
Given CD20 CAR T cell IV
CyclophosphamideDRUG
Given IV
Laboratory Biomarker AnalysisOTHER
Correlative studies
LeukapheresisPROCEDURE
Undergo leukapheresis
Fludarabine PhosphateDRUG
Given IV

Study Locations

FacilityCityStateCountry
Fred Hutch/University of Washington Cancer ConsortiumSeattleWashingtonUnited States

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026