NCT03275493

Chimeric Antigen Receptor T Cells Against CD19 With Cytokine Release Syndrome (CRS) Suppression Technology for Refractory/Relapsed CD19+ Acute Lymphoblastic Leukemia

Study Summary

This is a single center,randomized ,two-cohorts, open-label ,phase 1/2 study to evaluate the efficacy and safety of T cells expressing CD19 chimeric antigen receptors treatment for relapsed/refractory CD19+ acute lymphoblastic leukemia patients.

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Interventions

CD19 CAR-T cellsBIOLOGICAL
Express a Second Generation 4-1BB: CD19 CAR-T cells
CD19 CAR-T cells with CRS suppression technologyBIOLOGICAL
Express a Second Generation 4-1BB:CD19 CAR-T cells with CRS suppression technology

Study Locations

FacilityCityStateCountry
The first affiliated hospital of soochow universitySuzhouJiangsuChina

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026