NCT01769911

AUTOLOGOUS TRANSPLANTATION AND STEM CELL BASED-GENE THERAPY FOR THE TREATMENT OF HIV-ASSOCIATED LYMPHOMA

Study Summary

This clinical trial studies genetically modified peripheral blood stem cell transplant in treating patients with HIV-associated non-Hodgkin or Hodgkin lymphoma. Giving chemotherapy before a peripheral stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy or radiation therapy is then given to prepare the bone marrow for the stem cell transplant. Laboratory-treated stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy and radiation therapy

Want to learn more about this trial?

Request More Info

Interventions

carmustineDRUG
Given IV
cytarabineDRUG
Given IV
melphalanDRUG
Given IV
etoposideDRUG
Given IV
O6-benzylguanineDRUG
Given IV
autologous hematopoietic stem cell transplantationPROCEDURE
Undergo transduced and/or non-transduced transplant
peripheral blood stem cell transplantationPROCEDURE
Undergo transduced and/or non-transduced transplant
laboratory biomarker analysisOTHER
Correlative studies

Study Locations

FacilityCityStateCountry
Fred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumSeattleWashingtonUnited States

Official Trial Information

View on ClinicalTrials.gov

Data sourced from ClinicalTrials.gov. Last updated: April 14, 2026